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This course is designed to provide students with knowledge on how the body handles the drugs once administered into the body. The strategy for optimum treatment of patients with drugs is to give sufficient amounts for the required therapeutic effect to arise, but not the toxic effect. Pharmacokinetics is a branch of Therapeutics that includes; the study of mechanisms of absorption and distribution of an administered drug, the rate at which a drug action begins and the duration of the effect, the chemical changes of the drug in the body (metabolism by enzymes) and the effects and routes of excretion of the metabolites of the drug or intact drug. It examines the relationships among dose, plasma concentration and the subsequent therapeutic or toxic effect. The application of Pharmacokinetic concepts to clinical practice enables safe and effective therapeutic management of individual patients.
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